The IGF-I Generation Test Revisited: A Marker of GH Sensitivity
نویسندگان
چکیده
منابع مشابه
The GH/IGF-I axis and longevity.
Several converging lines of evidence obtained over the last years in a wide variety of experimental model organisms suggest that the ageing process is regulated by genes that encode proteins from the somatotroph axis: longevity genes like daf-2, which were identified using mutant Caenorhabditis elegans strains, turned out to be orthologues of the mammalian genes encoding insulin-like signalling...
متن کاملSensitivity to exogenous GH and reversibility of the reduced IGF-I gene expression in aging rats.
BACKGROUND IGF-I gene expression and IGF-I plasma concentration decline with age. A decreased sensitivity to GH has been suggested to be a contributory mechanism to this, in addition to attenuated GH secretion. OBJECTIVE This study focuses on the sensitivity to exogenous GH and the reversibility of the reduced IGF-I gene expression in aging male rats. DESIGN Three groups of male Wistar rats...
متن کاملGH response to provocation and circulating IGF-I and IGF-binding protein-3 concentrations, the IGF-I generation test and clinical response to GH therapy in children with beta-thalassaemia.
The causes of growth retardation of children with thalassaemia major are multifactorial. We studied the GH response to provocation by clonidine and glucagon, measured the circulating concentrations of insulin, IGF-I, IGF-binding protein-3 (IGFBP-3) and ferritin, and evaluated IGF-I generation after a single dose of GH (0.1 mg/kg per dose) in 15 prepubertal patients with thalassaemia, 15 age-mat...
متن کاملEmerging role of the GH/IGF-I on cardiometabolic control.
Growth hormone (GH), the main regulator for post-natal growth, has important metabolic actions on different tissues, similar or opposite to insulin like growth factor I (IGF-I), mainly produced by the liver after the binding of GH to its receptor. Experiments with animal models indicate an important role of GH on insulin resistance although the IGF-I role is not yet completely established. In h...
متن کاملBiochemical markers of acromegaly: GH vs. IGF-I.
The development of sensitive and specific growth hormone (GH) and insulin-like growth factor I (IGF-I) assays opened a new page in the diagnosis and surveillance of acromegaly. Currently, it is possible to make an accurate pre-operative diagnosis even in patients with virtually no typical clinical signs of the disease and to monitor the efficacy of therapeutic intervention with a high degree of...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2001
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem.86.11.8019